Betamethasone Sodium Phosphate
Brand names,
Betamethasone Sodium Phosphate
Analogs
Betamethasone Sodium Phosphate
Brand Names Mixture
- Lotrisone (betamethasone + clotrimazole)
Betamethasone Sodium Phosphate
Chemical_Formula
C22H29FO5
Betamethasone Sodium Phosphate
RX_link
http://www.rxlist.com/cgi/generic2/betamet.htm
Betamethasone Sodium Phosphate
fda sheet
Betamethasone Sodium Phosphate
msds (material safety sheet)
Betamethasone Sodium Phosphate
Synthesis Reference
Taub et al., J. Am. Chem. Soc. 80, 4435 (1958)
Betamethasone Sodium Phosphate
Molecular Weight
392.461 g/mol
Betamethasone Sodium Phosphate
Melting Point
231-234oC
Betamethasone Sodium Phosphate
H2O Solubility
Insoluble
Betamethasone Sodium Phosphate
State
Solid
Betamethasone Sodium Phosphate
LogP
1.772
Betamethasone Sodium Phosphate
Dosage Forms
Oral Solution; Tablet; Solution for Injection; Injectable Suspension; Cream; Gel; Ointment; Foam; Lotion
Betamethasone Sodium Phosphate
Indication
Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp
Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.
Betamethasone Sodium Phosphate
Pharmacology
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.
Betamethasone Sodium Phosphate
Absorption
Minimal if applied topically.
Betamethasone Sodium Phosphate
side effects and Toxicity
Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.
Betamethasone Sodium Phosphate
Patient Information
Patients using topical corticosteroids should receive the following information and instructions. This information
is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse
or intended effects.
1. This medication is to be used as directed by the physician and should not be used longer than the prescribed
time period. It is for external use only. Avoid contact with the eyes.
2. Patients should be advised not to use this medication for any disorder other than that for which it was
prescribed.
3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive.
4. Patients should report any signs of local adverse reactions.
5. Other corticosteroid-containing products should not be used with DIPROLENE AF Cream without first talking to
your physician.
Betamethasone Sodium Phosphate
Organisms Affected
Humans and other mammals