Rinderon
Brand names,
Rinderon
Analogs
Rinderon
Brand Names Mixture
- Lotrisone (betamethasone + clotrimazole)
Rinderon
Chemical_Formula
C22H29FO5
Rinderon
RX_link
http://www.rxlist.com/cgi/generic2/betamet.htm
Rinderon
fda sheet
Rinderon
msds (material safety sheet)
Rinderon
Synthesis Reference
Taub et al., J. Am. Chem. Soc. 80, 4435 (1958)
Rinderon
Molecular Weight
392.461 g/mol
Rinderon
Melting Point
231-234oC
Rinderon
H2O Solubility
Insoluble
Rinderon
State
Solid
Rinderon
LogP
1.772
Rinderon
Dosage Forms
Oral Solution; Tablet; Solution for Injection; Injectable Suspension; Cream; Gel; Ointment; Foam; Lotion
Rinderon
Indication
Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp
Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.
Rinderon
Pharmacology
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.
Rinderon
Absorption
Minimal if applied topically.
Rinderon
side effects and Toxicity
Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.
Rinderon
Patient Information
Patients using topical corticosteroids should receive the following information and instructions. This information
is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse
or intended effects.
1. This medication is to be used as directed by the physician and should not be used longer than the prescribed
time period. It is for external use only. Avoid contact with the eyes.
2. Patients should be advised not to use this medication for any disorder other than that for which it was
prescribed.
3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive.
4. Patients should report any signs of local adverse reactions.
5. Other corticosteroid-containing products should not be used with DIPROLENE AF Cream without first talking to
your physician.
Rinderon
Organisms Affected
Humans and other mammals