Atracurium

• Neuromuscular Nondepolarizing Agents
• Nicotinic Antagonists
• ATC:M03AC04
• ATC:M03AC11

• Atracurium Besylate
• Atracurium Besylate Preservative Free
• Nimbex
• Tracrium Preservative Free

• No information avaliable

C₅₃H₇₂N₂O₁₂+₂

http://www.rxlist.com/cgi/generic2/trac.htm

Atracurium MSDS

No information avaliable

929.145 g/mol

185-194 ^oC

Miscible

Solid

No information avaliable

Injection (10mg/mL)

For use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Atracurium is a nondepolarizing skeletal muscle relaxant. Atracurium can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. The duration of neuromuscular block produced by Atracurium is approximately one third to one half the duration of block by d-tubocurarine, metocurine, and pancuronium at initially equipotent doses. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of Atracurium. Repeated administration of maintenance doses of Atracurium has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.

No information avaliable

Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension.

Humans and other mammals