Atracurium
Brand names,
Atracurium
Analogs
Atracurium
Brand Names Mixture
Atracurium
Chemical_Formula
C53H72N2O12+2
Atracurium
RX_link
http://www.rxlist.com/cgi/generic2/trac.htm
Atracurium
fda sheet
Atracurium
msds (material safety sheet)
Atracurium
Synthesis Reference
No information avaliable
Atracurium
Molecular Weight
929.145 g/mol
Atracurium
Melting Point
185-194 oC
Atracurium
H2O Solubility
Miscible
Atracurium
State
Solid
Atracurium
LogP
No information avaliable
Atracurium
Dosage Forms
Injection (10mg/mL)
Atracurium
Indication
For use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Atracurium
Pharmacology
Atracurium is a nondepolarizing skeletal muscle relaxant. Atracurium can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. The duration of neuromuscular block produced by Atracurium is approximately one third to one half the duration of block by d-tubocurarine, metocurine, and pancuronium at initially equipotent doses. As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of Atracurium. Repeated administration of maintenance doses of Atracurium has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. Moreover, the time needed to recover from repeat doses does not change with additional doses. Repeat doses can therefore be administered at relatively regular intervals with predictable results.
Atracurium
Absorption
No information avaliable
Atracurium
side effects and Toxicity
Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension.
Atracurium
Patient Information
Atracurium
Organisms Affected
Humans and other mammals