Arava

Arava Brand names, Arava Analogs

Arava Brand Names Mixture

No information avaliable

Arava Chemical_Formula

C₁₂H₉F₃N₂O₂

Arava RX_link

http://www.rxlist.com/cgi/generic3/leflunomide.htm

Arava fda sheet

Arava FDA

Arava msds (material safety sheet)

Arava MSDS

Arava Synthesis Reference

No information avaliable

Arava Molecular Weight

270.207 g/mol

Arava Melting Point

165-166 ^oC

Arava H₂O Solubility

21 mg/L (poorly soluble)

Arava State

Solid

Arava LogP

2.659

Arava Dosage Forms

Tablet

Arava Indication

For the treatment of active rheumatoid arthritis (RA).

Arava Pharmacology

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomide's inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis.

Arava Absorption

Well absorbed, peak plasma concentrations appear 6-12 hours after dosing

Arava side effects and Toxicity

LD₅₀=100-250 mg/kg (acute oral toxicity)

Arava Patient Information