Leflunomidum [Inn-Latin]

Leflunomidum [Inn-Latin] Brand names, Leflunomidum [Inn-Latin] Analogs

Leflunomidum [Inn-Latin] Brand Names Mixture

No information avaliable

Leflunomidum [Inn-Latin] Chemical_Formula

C₁₂H₉F₃N₂O₂

Leflunomidum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic3/leflunomide.htm

Leflunomidum [Inn-Latin] fda sheet

Leflunomidum_[Inn-Latin] FDA

Leflunomidum [Inn-Latin] msds (material safety sheet)

Leflunomidum_[Inn-Latin] MSDS

Leflunomidum [Inn-Latin] Synthesis Reference

No information avaliable

Leflunomidum [Inn-Latin] Molecular Weight

270.207 g/mol

Leflunomidum [Inn-Latin] Melting Point

165-166 ^oC

Leflunomidum [Inn-Latin] H₂O Solubility

21 mg/L (poorly soluble)

Leflunomidum [Inn-Latin] State

Solid

Leflunomidum [Inn-Latin] LogP

2.659

Leflunomidum [Inn-Latin] Dosage Forms

Tablet

Leflunomidum [Inn-Latin] Indication

For the treatment of active rheumatoid arthritis (RA).

Leflunomidum [Inn-Latin] Pharmacology

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomide's inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis.

Leflunomidum [Inn-Latin] Absorption

Well absorbed, peak plasma concentrations appear 6-12 hours after dosing

Leflunomidum [Inn-Latin] side effects and Toxicity

LD₅₀=100-250 mg/kg (acute oral toxicity)

Leflunomidum [Inn-Latin] Patient Information