PharmacyCodes



Amiodarone en es it fr

Amiodarone Brand names, Amiodarone Analogs

Amiodarone Brand Names Mixture

  • No information avaliable

Amiodarone Chemical_Formula

C25H29I2NO3

Amiodarone RX_link

http://www.rxlist.com/cgi/generic/amiodarone.htm

Amiodarone fda sheet

Amiodarone FDA

Amiodarone msds (material safety sheet)

Amiodarone MSDS

Amiodarone Synthesis Reference

No information avaliable

Amiodarone Molecular Weight

645.312 g/mol

Amiodarone Melting Point

No information avaliable

Amiodarone H2O Solubility

Low

Amiodarone State

Solid

Amiodarone LogP

7.706

Amiodarone Dosage Forms

Liquid; Solution; Tablet (200 mg and 400 mg)

Amiodarone Indication

Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.

Amiodarone Pharmacology

Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.

Amiodarone Absorption

Slow and variable (about 20 to 55% of an oral dose is absorbed).

Amiodarone side effects and Toxicity

Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.

Amiodarone Patient Information

No information avaliable

Amiodarone Organisms Affected

Humans and other mammals