pms-Amiodarone
pms-Amiodarone Brand names, pms-Amiodarone Analogs
pms-Amiodarone Brand Names Mixture
- No information avaliable
pms-Amiodarone Chemical_Formula
C25H29I2NO3
pms-Amiodarone RX_link
http://www.rxlist.com/cgi/generic/amiodarone.htm
pms-Amiodarone fda sheet
pms-Amiodarone msds (material safety sheet)
pms-Amiodarone Synthesis Reference
No information avaliable
pms-Amiodarone Molecular Weight
645.312 g/mol
pms-Amiodarone Melting Point
No information avaliable
pms-Amiodarone H2O Solubility
Low
pms-Amiodarone State
Solid
pms-Amiodarone LogP
7.706
pms-Amiodarone Dosage Forms
Liquid; Solution; Tablet (200 mg and 400 mg)
pms-Amiodarone Indication
Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
pms-Amiodarone Pharmacology
Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.
pms-Amiodarone Absorption
Slow and variable (about 20 to 55% of an oral dose is absorbed).
pms-Amiodarone side effects and Toxicity
Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.
pms-Amiodarone Patient Information
No information avaliable
pms-Amiodarone Organisms Affected
Humans and other mammals
