Cordarone Intravenous
Cordarone Intravenous Brand names, Cordarone Intravenous Analogs
Cordarone Intravenous Brand Names Mixture
- No information avaliable
Cordarone Intravenous Chemical_Formula
C25H29I2NO3
Cordarone Intravenous RX_link
http://www.rxlist.com/cgi/generic/amiodarone.htm
Cordarone Intravenous fda sheet
Cordarone Intravenous msds (material safety sheet)
Cordarone Intravenous Synthesis Reference
No information avaliable
Cordarone Intravenous Molecular Weight
645.312 g/mol
Cordarone Intravenous Melting Point
No information avaliable
Cordarone Intravenous H2O Solubility
Low
Cordarone Intravenous State
Solid
Cordarone Intravenous LogP
7.706
Cordarone Intravenous Dosage Forms
Liquid; Solution; Tablet (200 mg and 400 mg)
Cordarone Intravenous Indication
Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
Cordarone Intravenous Pharmacology
Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.
Cordarone Intravenous Absorption
Slow and variable (about 20 to 55% of an oral dose is absorbed).
Cordarone Intravenous side effects and Toxicity
Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.
Cordarone Intravenous Patient Information
No information avaliable
Cordarone Intravenous Organisms Affected
Humans and other mammals
