PharmacyCodes



Amiodarone HCL en es it fr

Amiodarone HCL Brand names, Amiodarone HCL Analogs

Amiodarone HCL Brand Names Mixture

  • No information avaliable

Amiodarone HCL Chemical_Formula

C25H29I2NO3

Amiodarone HCL RX_link

http://www.rxlist.com/cgi/generic/amiodarone.htm

Amiodarone HCL fda sheet

Amiodarone_HCL FDA

Amiodarone HCL msds (material safety sheet)

Amiodarone_HCL MSDS

Amiodarone HCL Synthesis Reference

No information avaliable

Amiodarone HCL Molecular Weight

645.312 g/mol

Amiodarone HCL Melting Point

No information avaliable

Amiodarone HCL H2O Solubility

Low

Amiodarone HCL State

Solid

Amiodarone HCL LogP

7.706

Amiodarone HCL Dosage Forms

Liquid; Solution; Tablet (200 mg and 400 mg)

Amiodarone HCL Indication

Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.

Amiodarone HCL Pharmacology

Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.

Amiodarone HCL Absorption

Slow and variable (about 20 to 55% of an oral dose is absorbed).

Amiodarone HCL side effects and Toxicity

Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.

Amiodarone HCL Patient Information

No information avaliable

Amiodarone HCL Organisms Affected

Humans and other mammals