(+-)-Trimeprazine
(+-)-Trimeprazine Brand names, (+-)-Trimeprazine Analogs
- (+-)-Alimemazine
- (+-)-Trimeprazine
- Alimemazine
- Alimemazine S,S-dioxide
- Alimezine
- Bayer 1219
- Dosegran
- Doxergan
- Dysedon
- Imakol
- Levoprome
- Methylpromazine
- Oxomemazin
- Oxomemazina [INN-Spanish]
- Oxomemazine
- Oxomemazine [DCF:INN]
- Oxomemazinum [INN-Latin]
- Oxymemazine
- Panectyl
- Repeltin
- Repetin
- Temaril
- Teralen
- Theralene
- Trimeperazine
- Trimeprazine 5,5-dioxide
- Trimeprazine hemi-(+)tartrate
- Trimeprazine Tartrat
- Trimeprazine Tartrate
- Vallergan
(+-)-Trimeprazine Brand Names Mixture
- Vanectyl-P Tablets (Prednisolone + Trimeprazine Tartrate)
(+-)-Trimeprazine Chemical_Formula
C18H22N2S
(+-)-Trimeprazine RX_link
No information avaliable
(+-)-Trimeprazine fda sheet
(+-)-Trimeprazine msds (material safety sheet)
(+-)-Trimeprazine Synthesis Reference
No information avaliable
(+-)-Trimeprazine Molecular Weight
298.447 g/mol
(+-)-Trimeprazine Melting Point
68 oC
(+-)-Trimeprazine H2O Solubility
0.942 mg/L
(+-)-Trimeprazine State
Solid
(+-)-Trimeprazine LogP
5.162
(+-)-Trimeprazine Dosage Forms
Tablet (2.5 mg); Syrup (2.5 mg/5mL); Capsule(5 mg)
(+-)-Trimeprazine Indication
Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).
(+-)-Trimeprazine Pharmacology
Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Trimeprazine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H1-antihistamines.
(+-)-Trimeprazine Absorption
Well absorbed in the digestive tract.
(+-)-Trimeprazine side effects and Toxicity
Symptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
(+-)-Trimeprazine Patient Information
Prescriber should notify the patient to report an form of confusion, sedation, or hypotension. Inform the patient to avoid driving and other hazardous activity if drowsiness occurs. Also inform the patient to avoid alcohol and other CNS depressants while on trimeprazine.
(+-)-Trimeprazine Organisms Affected
Humans and other mammals
