Bayer 1219
Brand names,
Bayer 1219
Analogs
Bayer 1219
Brand Names Mixture
- Vanectyl-P Tablets (Prednisolone + Trimeprazine Tartrate)
Bayer 1219
Chemical_Formula
C18H22N2S
Bayer 1219
RX_link
No information avaliable
Bayer 1219
fda sheet
Bayer 1219
msds (material safety sheet)
Bayer 1219
Synthesis Reference
No information avaliable
Bayer 1219
Molecular Weight
298.447 g/mol
Bayer 1219
Melting Point
68 oC
Bayer 1219
H2O Solubility
0.942 mg/L
Bayer 1219
State
Solid
Bayer 1219
LogP
5.162
Bayer 1219
Dosage Forms
Tablet (2.5 mg); Syrup (2.5 mg/5mL); Capsule(5 mg)
Bayer 1219
Indication
Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).
Bayer 1219
Pharmacology
Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Trimeprazine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H1-antihistamines.
Bayer 1219
Absorption
Well absorbed in the digestive tract.
Bayer 1219
side effects and Toxicity
Symptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
Bayer 1219
Patient Information
Prescriber should notify the patient to report an form of confusion, sedation, or hypotension. Inform the patient to avoid driving and other hazardous activity if drowsiness occurs. Also inform the patient to avoid alcohol and other CNS depressants while on trimeprazine.
Bayer 1219
Organisms Affected
Humans and other mammals