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7HP Nombres de marca, 7HP Analogos

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    • 7HP Formula quimica

    C5H4N4O

    7HP RX enlace

    http://www.rxlist.com/cgi/generic/allopur.htm

    7HP FDA hoja

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=133

    7HP MSDS (hoja de seguridad de materiales)

    7HP MSDS

    7HP Sintesis de referencia

    Robins, J. Am. Chem. Por lo tanto. 78, 784 (1956)

    7HP Peso molecular

    136.112 g/mol

    7HP Punto de fusion

    350 oC

    7HP H2O Solubilidad

    569 mg / L

    7HP Estado

    Solid

    7HP LogP

    -0.177

    7HP Formas de dosificacion

    Comprimido para administración oral (100 mg, 200 mg y 300 mg), inyección

    7HP Indicacion

    Para el tratamiento de la hiperuricemia asociados con la gota primaria o secundaria.

    7HP Farmacologia

    El alopurinol, un análogo estructural de la base de purina naturales hipoxantina, se utiliza para prevenir la gota y los cálculos renales debido a el ácido úrico o de oxalato de calcio y para el tratamiento de la nefropatía por ácido úrico, hiperuricemia, y algunos tumores sólidos.

    7HP Absorcion

    Aproximadamente el 90% es absorbido desde el tracto gastrointestinal.

    7HP Toxicidad

    LD50 = 214 mg / kg (en ratones)

    7HP Informacion de Pacientes

    Patients should be informed of the following:

    1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
    2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
    3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
    4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
    5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
    6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
    7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

    7HP Organismos afectados

    Humanos y otros mamíferos