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Urosin
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Urosin Brand names, Urosin Analogs

Urosin Brand Names Mixture

  • No information avaliable

Urosin Chemical_Formula

C5H4N4O

Urosin RX_link

http://www.rxlist.com/cgi/generic/allopur.htm

Urosin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=133

Urosin msds (material safety sheet)

Urosin MSDS

Urosin Synthesis Reference

Robins, J. Am. Chem. So. 78, 784 (1956)

Urosin Molecular Weight

136.112 g/mol

Urosin Melting Point

350 oC

Urosin H2O Solubility

569 mg/L

Urosin State

Solid

Urosin LogP

-0.177

Urosin Dosage Forms

Tablet for oral administration (100mg, 200mg and 300mg); Injection

Urosin Indication

For the treatment of hyperuricemia associated with primary or secondary gout.

Urosin Pharmacology

Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.

Urosin Absorption

Approximately 90% absorbed from the gastrointestinal tract.

Urosin side effects and Toxicity

LD50=214 mg/kg (in mice)

Urosin Patient Information

Patients should be informed of the following:

1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

Urosin Organisms Affected

Humans and other mammals