Allo-Puren

Category

Allo-Puren




Useful info

Allo-Puren Brand names, Allo-Puren Analogs

Allo-Puren Brand Names Mixture

  • No information avaliable

    • Allo-Puren Chemical_Formula

    C5H4N4O

    Allo-Puren RX_link

    http://www.rxlist.com/cgi/generic/allopur.htm

    Allo-Puren fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=133

    Allo-Puren msds (material safety sheet)

    Allo-Puren MSDS

    Allo-Puren Synthesis Reference

    Robins, J. Am. Chem. So. 78, 784 (1956)

    Allo-Puren Molecular Weight

    136.112 g/mol

    Allo-Puren Melting Point

    350 oC

    Allo-Puren H2O Solubility

    569 mg/L

    Allo-Puren State

    Solid

    Allo-Puren LogP

    -0.177

    Allo-Puren Dosage Forms

    Tablet for oral administration (100mg, 200mg and 300mg); Injection

    Allo-Puren Indication

    For the treatment of hyperuricemia associated with primary or secondary gout.

    Allo-Puren Pharmacology

    Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.

    Allo-Puren Absorption

    Approximately 90% absorbed from the gastrointestinal tract.

    Allo-Puren Toxicity

    LD50=214 mg/kg (in mice)

    Allo-Puren Patient Information

    Patients should be informed of the following:

    1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
    2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
    3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
    4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
    5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
    6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
    7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

    Allo-Puren Organisms Affected

    Humans and other mammals