Urbol

• Free Radical Scavengers
• Enzyme Inhibitors Antimetabolites
• Gout Suppressants
• ATC:M04AA01

• 7HP
• Adenock
• Ailural
• Allo-Puren
• Allopur
• Allopurinol Sodium
• Allopurinolum [Inn-Latin]
• Allozym
• Allural
• Aloprim
• Alopurinol [Inn-Spanish]
• Aloral
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• Ketobun-A
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• Monarch
• Nektrohan
• Progout
• Purinol
• Remid
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• Sigapurol
• Suspendol
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• Urbol
• Uricemil
• Uriprim
• Uripurinol
• Uritas
• Urobenyl
• Urolit
• Urosin
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• Zyloric

• No information avaliable

C₅H₄N₄O

http://www.rxlist.com/cgi/generic/allopur.htm

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=133

Urbol MSDS

Robins, J. Am. Chem. So. 78, 784 (1956)

136.112 g/mol

350 ^oC

569 mg/L

Solid

-0.177

Tablet for oral administration (100mg, 200mg and 300mg); Injection

For the treatment of hyperuricemia associated with primary or secondary gout.

Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.

Approximately 90% absorbed from the gastrointestinal tract.

LD₅₀=214 mg/kg (in mice)

Patients should be informed of the following:

1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.

2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.

3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.

4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.

5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.

6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.

7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

Humans and other mammals