Anoprolin

Category

Anoprolin




Useful info

Anoprolin Brand names, Anoprolin Analogs

Anoprolin Brand Names Mixture

  • No information avaliable

    • Anoprolin Chemical_Formula

    C5H4N4O

    Anoprolin RX_link

    http://www.rxlist.com/cgi/generic/allopur.htm

    Anoprolin fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=133

    Anoprolin msds (material safety sheet)

    Anoprolin MSDS

    Anoprolin Synthesis Reference

    Robins, J. Am. Chem. So. 78, 784 (1956)

    Anoprolin Molecular Weight

    136.112 g/mol

    Anoprolin Melting Point

    350 oC

    Anoprolin H2O Solubility

    569 mg/L

    Anoprolin State

    Solid

    Anoprolin LogP

    -0.177

    Anoprolin Dosage Forms

    Tablet for oral administration (100mg, 200mg and 300mg); Injection

    Anoprolin Indication

    For the treatment of hyperuricemia associated with primary or secondary gout.

    Anoprolin Pharmacology

    Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.

    Anoprolin Absorption

    Approximately 90% absorbed from the gastrointestinal tract.

    Anoprolin Toxicity

    LD50=214 mg/kg (in mice)

    Anoprolin Patient Information

    Patients should be informed of the following:

    1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
    2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
    3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
    4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
    5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
    6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
    7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

    Anoprolin Organisms Affected

    Humans and other mammals