Topotecan
Topotecan Brand names, Topotecan Analogs
Topotecan Brand Names Mixture
- No information avaliable
Topotecan Chemical_Formula
C23H23N3O5
Topotecan RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Topotecan fda sheet
Topotecan msds (material safety sheet)
Topotecan Synthesis Reference
No information avaliable
Topotecan Molecular Weight
421.446 g/mol
Topotecan Melting Point
213-218 oC
Topotecan H2O Solubility
1 mg/ml
Topotecan State
Solid
Topotecan LogP
1.21
Topotecan Dosage Forms
Powder for solution
Topotecan Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Topotecan Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Topotecan Absorption
No information avaliable
Topotecan side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Topotecan Patient Information
No information avaliable
Topotecan Organisms Affected
Humans and other mammals
