Topotecan Hydrochloride en es it fr

Topotecan Hydrochloride Brand names, Topotecan Hydrochloride Analogs

Topotecan Hydrochloride Brand Names Mixture

  • No information avaliable

Topotecan Hydrochloride Chemical_Formula

C23H23N3O5

Topotecan Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/topotec.htm

Topotecan Hydrochloride fda sheet

Topotecan_Hydrochloride FDA

Topotecan Hydrochloride msds (material safety sheet)

Topotecan_Hydrochloride MSDS

Topotecan Hydrochloride Synthesis Reference

No information avaliable

Topotecan Hydrochloride Molecular Weight

421.446 g/mol

Topotecan Hydrochloride Melting Point

213-218 oC

Topotecan Hydrochloride H2O Solubility

1 mg/ml

Topotecan Hydrochloride State

Solid

Topotecan Hydrochloride LogP

1.21

Topotecan Hydrochloride Dosage Forms

Powder for solution

Topotecan Hydrochloride Indication

For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.

Topotecan Hydrochloride Pharmacology

Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.

Topotecan Hydrochloride Absorption

No information avaliable

Topotecan Hydrochloride side effects and Toxicity

The primary anticipated complication of overdosage would consist of bone marrow suppression.

Topotecan Hydrochloride Patient Information

No information avaliable

Topotecan Hydrochloride Organisms Affected

Humans and other mammals