Topotecan Lactone en es it fr

Topotecan Lactone Brand names, Topotecan Lactone Analogs

Topotecan Lactone Brand Names Mixture

  • No information avaliable

Topotecan Lactone Chemical_Formula

C23H23N3O5

Topotecan Lactone RX_link

http://www.rxlist.com/cgi/generic2/topotec.htm

Topotecan Lactone fda sheet

Topotecan_Lactone FDA

Topotecan Lactone msds (material safety sheet)

Topotecan_Lactone MSDS

Topotecan Lactone Synthesis Reference

No information avaliable

Topotecan Lactone Molecular Weight

421.446 g/mol

Topotecan Lactone Melting Point

213-218 oC

Topotecan Lactone H2O Solubility

1 mg/ml

Topotecan Lactone State

Solid

Topotecan Lactone LogP

1.21

Topotecan Lactone Dosage Forms

Powder for solution

Topotecan Lactone Indication

For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.

Topotecan Lactone Pharmacology

Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.

Topotecan Lactone Absorption

No information avaliable

Topotecan Lactone side effects and Toxicity

The primary anticipated complication of overdosage would consist of bone marrow suppression.

Topotecan Lactone Patient Information

No information avaliable

Topotecan Lactone Organisms Affected

Humans and other mammals