Topotecan Hcl
Topotecan Hcl Brand names, Topotecan Hcl Analogs
Topotecan Hcl Brand Names Mixture
- No information avaliable
Topotecan Hcl Chemical_Formula
C23H23N3O5
Topotecan Hcl RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Topotecan Hcl fda sheet
Topotecan Hcl msds (material safety sheet)
Topotecan Hcl Synthesis Reference
No information avaliable
Topotecan Hcl Molecular Weight
421.446 g/mol
Topotecan Hcl Melting Point
213-218 oC
Topotecan Hcl H2O Solubility
1 mg/ml
Topotecan Hcl State
Solid
Topotecan Hcl LogP
1.21
Topotecan Hcl Dosage Forms
Powder for solution
Topotecan Hcl Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Topotecan Hcl Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Topotecan Hcl Absorption
No information avaliable
Topotecan Hcl side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Topotecan Hcl Patient Information
No information avaliable
Topotecan Hcl Organisms Affected
Humans and other mammals
