TPT

• Antineoplastic Agents
• Enzyme Inhibitors
• ATC:L01XX17

• Hycamptamine
• Hycamptin
• Hycamtin
• TOPOTECAN, HYCAMTIN
• TPT
• TTC
• Topotecan Hcl
• Topotecan Hydrochloride
• Topotecan Lactone
• Topotecane [Inn-French]
• Topotecanum [Inn-Latin]

• No information avaliable

C₂₃H₂₃N₃O₅

http://www.rxlist.com/cgi/generic2/topotec.htm

TPT FDA

TPT MSDS

No information avaliable

421.446 g/mol

213-218 ^oC

1 mg/ml

Solid

1.21

Powder for solution

For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.

Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.

No information avaliable

The primary anticipated complication of overdosage would consist of bone marrow suppression.

No information avaliable

Humans and other mammals