Gyne-Lotrimin_3_Combination_Pack
Category
Gyne-Lotrimin_3_Combination_Pack Brand names, Gyne-Lotrimin_3_Combination_Pack Analogs
Gyne-Lotrimin_3_Combination_Pack Brand Names Mixture
Lotrisone (clotrimazole + betamethasone)
Gyne-Lotrimin_3_Combination_Pack Chemical_Formula
C22H17ClN2
Gyne-Lotrimin_3_Combination_Pack RX_link
http://www.rxlist.com/cgi/generic2/clotrimaz.htm
Gyne-Lotrimin_3_Combination_Pack fda sheet
Gyne-Lotrimin_3_Combination_Pack msds (material safety sheet)
Gyne-Lotrimin_3_Combination_Pack Synthesis Reference
K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)
Gyne-Lotrimin_3_Combination_Pack Molecular Weight
344.837 g/mol
Gyne-Lotrimin_3_Combination_Pack Melting Point
147-149 oC
Gyne-Lotrimin_3_Combination_Pack H2O Solubility
29.84 mg/mL
Gyne-Lotrimin_3_Combination_Pack State
Solid
Gyne-Lotrimin_3_Combination_Pack LogP
5.98
Gyne-Lotrimin_3_Combination_Pack Dosage Forms
Cream; Liquid; Solution; Suppository; Ointment; Lozenge
Gyne-Lotrimin_3_Combination_Pack Indication
For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Gyne-Lotrimin_3_Combination_Pack Pharmacology
Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.
Gyne-Lotrimin_3_Combination_Pack Absorption
Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Gyne-Lotrimin_3_Combination_Pack Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Gyne-Lotrimin_3_Combination_Pack Patient Information
How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.
Gyne-Lotrimin_3_Combination_Pack Organisms Affected
Yeast and other fungi
