Clotrimazole_ZnSO4_complex
Category
Clotrimazole_ZnSO4_complex Brand names, Clotrimazole_ZnSO4_complex Analogs
Clotrimazole_ZnSO4_complex Brand Names Mixture
Lotrisone (clotrimazole + betamethasone)
Clotrimazole_ZnSO4_complex Chemical_Formula
C22H17ClN2
Clotrimazole_ZnSO4_complex RX_link
http://www.rxlist.com/cgi/generic2/clotrimaz.htm
Clotrimazole_ZnSO4_complex fda sheet
Clotrimazole_ZnSO4_complex msds (material safety sheet)
Clotrimazole_ZnSO4_complex Synthesis Reference
K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)
Clotrimazole_ZnSO4_complex Molecular Weight
344.837 g/mol
Clotrimazole_ZnSO4_complex Melting Point
147-149 oC
Clotrimazole_ZnSO4_complex H2O Solubility
29.84 mg/mL
Clotrimazole_ZnSO4_complex State
Solid
Clotrimazole_ZnSO4_complex LogP
5.98
Clotrimazole_ZnSO4_complex Dosage Forms
Cream; Liquid; Solution; Suppository; Ointment; Lozenge
Clotrimazole_ZnSO4_complex Indication
For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Clotrimazole_ZnSO4_complex Pharmacology
Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.
Clotrimazole_ZnSO4_complex Absorption
Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Clotrimazole_ZnSO4_complex Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Clotrimazole_ZnSO4_complex Patient Information
How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.
Clotrimazole_ZnSO4_complex Organisms Affected
Yeast and other fungi
