Canesten_3-Day_Therapy
Category
Canesten_3-Day_Therapy Brand names, Canesten_3-Day_Therapy Analogs
Canesten_3-Day_Therapy Brand Names Mixture
Lotrisone (clotrimazole + betamethasone)
Canesten_3-Day_Therapy Chemical_Formula
C22H17ClN2
Canesten_3-Day_Therapy RX_link
http://www.rxlist.com/cgi/generic2/clotrimaz.htm
Canesten_3-Day_Therapy fda sheet
Canesten_3-Day_Therapy msds (material safety sheet)
Canesten_3-Day_Therapy Synthesis Reference
K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)
Canesten_3-Day_Therapy Molecular Weight
344.837 g/mol
Canesten_3-Day_Therapy Melting Point
147-149 oC
Canesten_3-Day_Therapy H2O Solubility
29.84 mg/mL
Canesten_3-Day_Therapy State
Solid
Canesten_3-Day_Therapy LogP
5.98
Canesten_3-Day_Therapy Dosage Forms
Cream; Liquid; Solution; Suppository; Ointment; Lozenge
Canesten_3-Day_Therapy Indication
For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Canesten_3-Day_Therapy Pharmacology
Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.
Canesten_3-Day_Therapy Absorption
Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Canesten_3-Day_Therapy Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Canesten_3-Day_Therapy Patient Information
How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.
Canesten_3-Day_Therapy Organisms Affected
Yeast and other fungi
