Lotrimin_AF_Jock-Itch_Cream
Category
Lotrimin_AF_Jock-Itch_Cream Brand names, Lotrimin_AF_Jock-Itch_Cream Analogs
Lotrimin_AF_Jock-Itch_Cream Brand Names Mixture
Lotrisone (clotrimazole + betamethasone)
Lotrimin_AF_Jock-Itch_Cream Chemical_Formula
C22H17ClN2
Lotrimin_AF_Jock-Itch_Cream RX_link
http://www.rxlist.com/cgi/generic2/clotrimaz.htm
Lotrimin_AF_Jock-Itch_Cream fda sheet
Lotrimin_AF_Jock-Itch_Cream msds (material safety sheet)
Lotrimin_AF_Jock-Itch_Cream Synthesis Reference
K. H. Buechel et al.; U.S. Pat. 4,705,172(1972)
Lotrimin_AF_Jock-Itch_Cream Molecular Weight
344.837 g/mol
Lotrimin_AF_Jock-Itch_Cream Melting Point
147-149 oC
Lotrimin_AF_Jock-Itch_Cream H2O Solubility
29.84 mg/mL
Lotrimin_AF_Jock-Itch_Cream State
Solid
Lotrimin_AF_Jock-Itch_Cream LogP
5.98
Lotrimin_AF_Jock-Itch_Cream Dosage Forms
Cream; Liquid; Solution; Suppository; Ointment; Lozenge
Lotrimin_AF_Jock-Itch_Cream Indication
For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Lotrimin_AF_Jock-Itch_Cream Pharmacology
Clotrimazole, an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. In studies in fungal cultures, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. Both of these events began rapidly and extensively after addition of the drug to the cultures. The primary action of clotrimazole is against dividing and growing organisms.
Lotrimin_AF_Jock-Itch_Cream Absorption
Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Lotrimin_AF_Jock-Itch_Cream Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Lotrimin_AF_Jock-Itch_Cream Patient Information
How to use Clotrimazole :Use clotrimazole exactly as directed by your doctor. Always
read the manufacturer's information leaflet, if possible, before beginning treatment.
Clotrimazole preparations are usually applied two to three times a day until the
infection has cleared. This medicine is for you. Never give it to others, even if
their condition appears to be the same as yours. Getting the most from your
treatment : Always wash and dry your hands thoroughly before and after handling
clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears,
or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised
to do so by your doctor. Complete the full course of treatment with clotrimazole,
otherwise your infection is likely to recur. Before using any 'over-the-counter'
medicines, check with your pharmacist which medicines are safe for you to use alongside
clotrimazole. You should see an improvement in your condition after a few days.
If your condition does not seem to be getting better after seven days, consult your
doctor for advice.
Lotrimin_AF_Jock-Itch_Cream Organisms Affected
Yeast and other fungi
