Anusol_HC

Category

Anusol_HC




Useful info

Anusol_HC Brand names, Anusol_HC Analogs

Anusol_HC Brand Names Mixture

  • No information avaliable

    • Anusol_HC Chemical_Formula

    C21H30O5

    Anusol_HC RX_link

    http://www.rxlist.com/cgi/generic/hydrocortisone.htm

    Anusol_HC fda sheet

    Anusol_HC FDA

    Anusol_HC msds (material safety sheet)

    Anusol_HC MSDS

    Anusol_HC Synthesis Reference

    No information avaliable

    Anusol_HC Molecular Weight

    362.46 g/mol

    Anusol_HC Melting Point

    220 oC

    Anusol_HC H2O Solubility

    320 mg/L

    Anusol_HC State

    Solid

    Anusol_HC LogP

    1.692

    Anusol_HC Dosage Forms

    Cream; Ointment; Enemas

    Anusol_HC Indication

    For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

    Anusol_HC Pharmacology

    Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

    Anusol_HC Absorption

    Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

    Anusol_HC Toxicity

    Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

    Anusol_HC Patient Information

    No information avaliable

    Anusol_HC Organisms Affected

    Humans and other mammals