Hydrocortisone Sodium Phosphate

Hydrocortisone Sodium Phosphate Brand names, Hydrocortisone Sodium Phosphate Analogs

Hydrocortisone Sodium Phosphate Brand Names Mixture

No information avaliable

Hydrocortisone Sodium Phosphate Chemical_Formula

C₂₁H₃₀O₅

Hydrocortisone Sodium Phosphate RX_link

http://www.rxlist.com/cgi/generic/hydrocortisone.htm

Hydrocortisone Sodium Phosphate fda sheet

Hydrocortisone_Sodium_Phosphate FDA

Hydrocortisone Sodium Phosphate msds (material safety sheet)

Hydrocortisone_Sodium_Phosphate MSDS

Hydrocortisone Sodium Phosphate Synthesis Reference

No information avaliable

Hydrocortisone Sodium Phosphate Molecular Weight

362.46 g/mol

Hydrocortisone Sodium Phosphate Melting Point

220 ^oC

Hydrocortisone Sodium Phosphate H₂O Solubility

320 mg/L

Hydrocortisone Sodium Phosphate State

Solid

Hydrocortisone Sodium Phosphate LogP

1.692

Hydrocortisone Sodium Phosphate Dosage Forms

Cream; Ointment; Enemas

Hydrocortisone Sodium Phosphate Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Hydrocortisone Sodium Phosphate Pharmacology

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Hydrocortisone Sodium Phosphate Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Hydrocortisone Sodium Phosphate side effects and Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Hydrocortisone Sodium Phosphate Patient Information