17alpha-Hydroxycorticosterone
Category
17alpha-Hydroxycorticosterone Brand names, 17alpha-Hydroxycorticosterone Analogs
17alpha-Hydroxycorticosterone Brand Names Mixture
No information avaliable
17alpha-Hydroxycorticosterone Chemical_Formula
C21H30O5
17alpha-Hydroxycorticosterone RX_link
http://www.rxlist.com/cgi/generic/hydrocortisone.htm
17alpha-Hydroxycorticosterone fda sheet
17alpha-Hydroxycorticosterone msds (material safety sheet)
17alpha-Hydroxycorticosterone Synthesis Reference
No information avaliable
17alpha-Hydroxycorticosterone Molecular Weight
362.46 g/mol
17alpha-Hydroxycorticosterone Melting Point
220 oC
17alpha-Hydroxycorticosterone H2O Solubility
320 mg/L
17alpha-Hydroxycorticosterone State
Solid
17alpha-Hydroxycorticosterone LogP
1.692
17alpha-Hydroxycorticosterone Dosage Forms
Cream; Ointment; Enemas
17alpha-Hydroxycorticosterone Indication
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
17alpha-Hydroxycorticosterone Pharmacology
Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
17alpha-Hydroxycorticosterone Absorption
Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
17alpha-Hydroxycorticosterone Toxicity
Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
17alpha-Hydroxycorticosterone Patient Information
No information avaliable
17alpha-Hydroxycorticosterone Organisms Affected
Humans and other mammals
