H-Cort

Category

H-Cort




Useful info

H-Cort Brand names, H-Cort Analogs

H-Cort Brand Names Mixture

  • No information avaliable

    • H-Cort Chemical_Formula

    C21H30O5

    H-Cort RX_link

    http://www.rxlist.com/cgi/generic/hydrocortisone.htm

    H-Cort fda sheet

    H-Cort FDA

    H-Cort msds (material safety sheet)

    H-Cort MSDS

    H-Cort Synthesis Reference

    No information avaliable

    H-Cort Molecular Weight

    362.46 g/mol

    H-Cort Melting Point

    220 oC

    H-Cort H2O Solubility

    320 mg/L

    H-Cort State

    Solid

    H-Cort LogP

    1.692

    H-Cort Dosage Forms

    Cream; Ointment; Enemas

    H-Cort Indication

    For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

    H-Cort Pharmacology

    Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

    H-Cort Absorption

    Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

    H-Cort Toxicity

    Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

    H-Cort Patient Information

    No information avaliable

    H-Cort Organisms Affected

    Humans and other mammals