Ala-cort
Category
Ala-cort Brand names, Ala-cort Analogs
Ala-cort Brand Names Mixture
No information avaliable
Ala-cort Chemical_Formula
C21H30O5
Ala-cort RX_link
http://www.rxlist.com/cgi/generic/hydrocortisone.htm
Ala-cort fda sheet
Ala-cort msds (material safety sheet)
Ala-cort Synthesis Reference
No information avaliable
Ala-cort Molecular Weight
362.46 g/mol
Ala-cort Melting Point
220 oC
Ala-cort H2O Solubility
320 mg/L
Ala-cort State
Solid
Ala-cort LogP
1.692
Ala-cort Dosage Forms
Cream; Ointment; Enemas
Ala-cort Indication
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Ala-cort Pharmacology
Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Ala-cort Absorption
Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Ala-cort Toxicity
Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
Ala-cort Patient Information
No information avaliable
Ala-cort Organisms Affected
Humans and other mammals
