Epival

• Antimanic Agents
• GABA Agents
• Anticonvulsants
• ATC:N03AG

• Convulex
• DPA
• Depakene
• Depakine
• Depakote
• Depakote CP
• Depakote ER
• Depakote Sprinkle
• Dipropylacetic acid
• Divalproex sodium
• Epilim
• Epival
• Ergenyl
• Mylproin
• N-dipropylacetic acid
• N-DPA
• Propylvaleric acid

No information avaliable

C₁₆H₃₁NaO₄

http://www.rxlist.com/cgi/generic/dival.htm

Epival FDA

Nessuna informazione disponibile

310.405 g/mol

222^oC

Leggermente solubile (2000 mg / L)

Solid

2.549

Tablet (rivestimento enterico - 125, 250, 500 mg)

Per il trattamento e la gestione dei disturbi convulsivi, mania, e il trattamento profilattico di emicrania.

Divalproex è una stabile coordinamento composto costituito da valproato di sodio e acido valproico in un rapporto 1:1 molare e si formano durante la parziale neutralizzazione di acido valproico con equivalente 0,5 di idrossido di sodio. Divalproex è un anticonvulsivante e stabilizzare l'umore farmaco utilizzato principalmente nel trattamento di epilessia e disturbo bipolare. E 'anche usato per trattare l'emicrania e la schizofrenia. Negli epilettici, valproato viene utilizzato per controllare crisi di assenza, crisi tonico-cloniche (grande male), crisi parziali complesse, e le crisi associate alla sindrome di Lennox-Gastaut. Divalproex si crede a pregiudicare la funzione del neurotrasmettitore GABA (come inibitore della GABA-transaminasi) nel cervello umano. Dissocia Divalproex allo ione valproato nel tratto gastrointestinale.

Un rapido assorbimento dal tratto gastrointestinale.

Sovradosaggio con valproato può causare sonnolenza, blocco cardiaco, e coma profondo. Infortuni mortali sono stati segnalati, tuttavia i pazienti hanno recuperato dai livelli divalproex alto come 2120 mg / ml.

Important Information for Women Who Could Become Pregnant About the Use of DEPAKOTE^® (divalproex sodium) Tablets

Please read this leaflet carefully before you take DEPAKOTE^® (divalproex sodium) tablets. This leaflet provides a summary of important information about taking DEPAKOTE to women who could become pregnant. If you have any questions or concerns,or want more information about DEPAKOTE, contact your doctor or pharmacist.

Information For Women Who Could Become Pregnant

DEPAKOTE can be obtained only by prescription from your doctor. The decision to use DEPAKOTE is one that you and your doctor should make together, taking into account your individual needs and medical condition.

Before using DEPAKOTE, women who can become pregnant should consider the fact that DEPAKOTE has been associated with birth defects, in particular, with spina bifida and other defects related to failure of the spinal canal to close normally. Approximately 1 to 2% of children born to women with epilepsy taking DEPAKOTE in the first 12 weeks of pregnancy had these defects (based on data from the Centers for Disease Control, a U.S. agency based in Atlanta). The incidence in the general population is 0.1 to 0.2%.

Information For Women Who Are Planning to Get Pregnant

ï Women taking DEPAKOTE who are planning to get pregnant should discuss the treatment options with their doctor.

Information For Women Who Become Pregnant While Taking DEPAKOTE

ï If you become pregnant while taking DEPAKOTE you should contact your doctor immediately.

Other Important Information About DEPAKOTE Tablets

ï DEPAKOTE tablets should be taken exactly as it is prescribed by your doctor to get the most benefits from DEPAKOTE and reduce the risk of side effects.

ï If you have taken more than the prescribed dose of DEPAKOTE, contact your hospital emergency room or local poison center immediately.

ï This medication was prescribed for your particular condition. Do not use it for another condition or give the drug to others.

Facts About Birth Defects

It is important to know that birth defects may occur even in children of individuals not taking any medications or without any additional risk factors.

This summary provides important information about the use of DEPAKOTE to women who could become pregnant. If you would like more information about the other potential risks and benefits of DEPAKOTE, ask your doctor or pharmacist to let you read the professional labeling and then discuss it with them. If you have any questions or concerns about taking DEPAKOTE, you should discuss them with your doctor.

Gli esseri umani e altri mammiferi