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Divalproex sodium Brand names, Divalproex sodium Analogs

Divalproex sodium Brand Names Mixture

  • No information avaliable

Divalproex sodium Chemical_Formula


Divalproex sodium RX_link


Divalproex sodium fda sheet

Divalproex_sodium FDA

Divalproex sodium msds (material safety sheet)

Divalproex sodium Synthesis Reference

No information avaliable

Divalproex sodium Molecular Weight

310.405 g/mol

Divalproex sodium Melting Point


Divalproex sodium H2O Solubility

Slightly soluble (2000 mg/L)

Divalproex sodium State


Divalproex sodium LogP


Divalproex sodium Dosage Forms

Tablet (enteric-coated - 125, 250, 500 mg)

Divalproex sodium Indication

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache.

Divalproex sodium Pharmacology

Divalproex is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Divalproex is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, divalproex is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. Divalproex is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Divalproex dissociates to the valproate ion in the gastrointestinal tract.

Divalproex sodium Absorption

Rapid absorption from gastrointestinal tract.

Divalproex sodium side effects and Toxicity

Overdosage with divalproex may result in somnolence,heart block,and deep coma. Fatalities have been reported; however patients have recovered from divalproex levels as high as 2120 µg/mL.

Divalproex sodium Patient Information

Important Information for Women Who Could Become Pregnant About the Use of DEPAKOTE® (divalproex sodium) Tablets

Please read this leaflet carefully before you take DEPAKOTE® (divalproex sodium) tablets. This leaflet provides a summary of important information about taking DEPAKOTE to women who could become pregnant. If you have any questions or concerns,or want more information about DEPAKOTE, contact your doctor or pharmacist.

Information For Women Who Could Become Pregnant

DEPAKOTE can be obtained only by prescription from your doctor. The decision to use DEPAKOTE is one that you and your doctor should make together, taking into account your individual needs and medical condition.

Before using DEPAKOTE, women who can become pregnant should consider the fact that DEPAKOTE has been associated with birth defects, in particular, with spina bifida and other defects related to failure of the spinal canal to close normally. Approximately 1 to 2% of children born to women with epilepsy taking DEPAKOTE in the first 12 weeks of pregnancy had these defects (based on data from the Centers for Disease Control, a U.S. agency based in Atlanta). The incidence in the general population is 0.1 to 0.2%.

Information For Women Who Are Planning to Get Pregnant

ï Women taking DEPAKOTE who are planning to get pregnant should discuss the treatment options with their doctor.

Information For Women Who Become Pregnant While Taking DEPAKOTE

ï If you become pregnant while taking DEPAKOTE you should contact your doctor immediately.

Other Important Information About DEPAKOTE Tablets

ï DEPAKOTE tablets should be taken exactly as it is prescribed by your doctor to get the most benefits from DEPAKOTE and reduce the risk of side effects.

ï If you have taken more than the prescribed dose of DEPAKOTE, contact your hospital emergency room or local poison center immediately.

ï This medication was prescribed for your particular condition. Do not use it for another condition or give the drug to others.

Facts About Birth Defects

It is important to know that birth defects may occur even in children of individuals not taking any medications or without any additional risk factors.

This summary provides important information about the use of DEPAKOTE to women who could become pregnant. If you would like more information about the other potential risks and benefits of DEPAKOTE, ask your doctor or pharmacist to let you read the professional labeling and then discuss it with them. If you have any questions or concerns about taking DEPAKOTE, you should discuss them with your doctor.

Divalproex sodium Organisms Affected

Humans and other mammals