Losartan
Categorie
Losartan Les marques, Losartan Analogs
Losartan Les marques melange
Losartan Formule chimique
C22H23ClN6O
Losartan RX lien
http://www.rxlist.com/cgi/generic/losar.htm
Losartan FDA fiche
Losartan msds (fiche de securite des materiaux)
Losartan Synthese de reference
DJ Carini et al., US. 5,138,69 (1992)
Losartan Poids moleculaire
422.911 g/mol
Losartan Point de fusion
183.5-184.5 oC
Losartan H2O Solubilite
Losartan Etat
Solid
Losartan LogP
5.438
Losartan Formes pharmaceutiques
Tablet
Losartan Indication
Pour le traitement de l'hypertension.
Losartan Pharmacologie
Le losartan est le premier d'une classe d'agents antihypertenseurs, l'angiotensine II (AG II) des antagonistes du récepteur. Il est, avec ses plus agissant métabolite actif (E-3174), une sélection spécifique et Antagoniste des récepteurs AT1. Le losartan bloque l'effet vasoconstricteur et de sécrétion d'aldostérone effets de l'angiotensine II en bloquant sélectivement la liaison de l'angiotensine II au récepteur AT1 trouve dans de nombreux tissus (par exemple, le muscle lisse vasculaire, glande surrénale).
Losartan Absorption
Eh bien absorbée, la biodisponibilité systémique du losartan est d'environ 33%
Losartan Toxicite
Hypotension et une tachycardie bradycardie peut survenir à partir parasympathique (vagal), DL50 = 1000 mg / kg (par voie orale chez le rat)
Losartan Information pour les patients
PATIENT INFORMATION
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Losartan Organismes affectes
Les humains et autres mammifères
