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Losartan Brand names, Losartan Analogs

Losartan Brand Names Mixture

  • Hyzaar

Losartan Chemical_Formula


Losartan RX_link


Losartan fda sheet

Losartan FDA

Losartan msds (material safety sheet)

Losartan MSDS

Losartan Synthesis Reference

D. J. Carini et al., U.S. Pat. 5,138,69 (1992)

Losartan Molecular Weight

422.911 g/mol

Losartan Melting Point

183.5-184.5 oC

Losartan H2O Solubility

0.82 mg/L

Losartan State


Losartan LogP


Losartan Dosage Forms


Losartan Indication

For the treatment of hypertension.

Losartan Pharmacology

Losartan is the first of a class of antihypertensive agents called angiotensin II (AG II) receptor antagonists. It is, along with its longer acting active metabolite (E-3174), a specific and selective AT1 receptor antagonist. Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland).

Losartan Absorption

Well absorbed, the systemic bioavailability of losartan is approximately 33%

Losartan side effects and Toxicity

Hypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD50= 1000 mg/kg (orally in rat)

Losartan Patient Information


Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly

Losartan Organisms Affected

Humans and other mammals