Lortaan
Lortaan Brand names, Lortaan Analogs
Lortaan Brand Names Mixture
- Hyzaar
Lortaan Chemical_Formula
C22H23ClN6O
Lortaan RX_link
http://www.rxlist.com/cgi/generic/losar.htm
Lortaan fda sheet
Lortaan msds (material safety sheet)
Lortaan Synthesis Reference
D. J. Carini et al., U.S. Pat. 5,138,69 (1992)
Lortaan Molecular Weight
422.911 g/mol
Lortaan Melting Point
183.5-184.5 oC
Lortaan H2O Solubility
0.82 mg/L
Lortaan State
Solid
Lortaan LogP
5.438
Lortaan Dosage Forms
Tablet
Lortaan Indication
For the treatment of hypertension.
Lortaan Pharmacology
Losartan is the first of a class of antihypertensive agents called angiotensin II (AG II) receptor antagonists. It is, along with its longer acting active metabolite (E-3174), a specific and selective AT1 receptor antagonist. Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland).
Lortaan Absorption
Well absorbed, the systemic bioavailability of losartan is approximately 33%
Lortaan side effects and Toxicity
Hypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD50= 1000 mg/kg (orally in rat)
Lortaan Patient Information
PATIENT INFORMATION
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Losartan potassium is used to treat high blood pressure. It may be used alone
or with other medications for high blood pressure. This medication should,
generally, not be used during pregnancy. If you are pregnant or considering
becoming pregnant, inform your physician immediately to discuss the risks
versus benefits. There are few side effects associated with losartan potassium.
Those most frequently reported, cough, upper respiratory infection and
dizziness, occurred no more frequently than in patients who did not take this
medication. You may take this medication with or without food. You should have
your blood pressure checked regularly
Lortaan Organisms Affected
Humans and other mammals
