Categorie
Histaloran
Les marques,
Histaloran
Analogs
Histaloran
Les marques melange
Chlor-Tripolon ND SRT (Loratadine + Pseudoephedrine Sulfate) Claritin Allergy + Sinus Extra Strength (Loratadine + Pseudoephedrine Sulfate) Liberator (Loratadine + Pseudoephedrine Sulfate)
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Formule chimique
C22H23ClN2O2
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RX lien
http://www.rxlist.com/cgi/generic/lorat.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
FJ Villani, le brevet américain. 4,282,233 (1981)
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Poids moleculaire
382.883 g/mol
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Point de fusion
134-136 oC
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H2O Solubilite
0.000011 mg / ml
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Etat
Solid
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LogP
3.646
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Formes pharmaceutiques
Tablet; Sirop
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Indication
Pour le soulagement des symptômes nasaux et non-nasaux de la rhinite allergique saisonnière et pour le traitement de l'urticaire idiopathique chronique chez les patients de 2 ans ou plus
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Pharmacologie
La loratadine, un antihistaminique non sédatif H1-bloqueur de structure similaire à la cyproheptadine et azatadine, est utilisé pour traiter la rhinite allergique saisonnière. Contrairement à d'autres H1-bloquants, loratidine ne pénètre pas le SNC de façon efficace et a une faible affinité pour les récepteurs H1 SNC.
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Absorption
Rapidement absorbé après administration orale (40% la biodisponibilité)
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Toxicite
somnolence, tachycardie, maux de tête et de DL50 = mg / kg (par voie orale chez le rat)
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Information pour les patients
Description
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This medicine is used to treat symptoms of hay fever such as runny nose,
watery eyes and sneezing. Your doctor may use antihistimines for other
conditions as well.
General Information
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This information is for educational purposes only. Not every known side
effect, adverse effect, or drug interaction is in this database. If you
have questions about your medicines, talk to your healthcare provider.
Proper use of this medicine
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For proper use of this medicine, follow the directions on the package,
unless otherwise instructed by your doctor.
Missed Dose
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If your doctor has instructed you to take this medicine regularly and you
miss a dose, take your next dose, as soon as you remember. If you are close
to your next dose, do not double up. Skip the missed dose and go back to
your regular schedule.
Storage
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Keep this medication in the container it came in, tightly closed, and out
of reach of children. Store it at room temperature and away from excess
heat and moisture (not in the bathroom). Throw away any medication that
is outdated or no longer needed.
Possible Side Effects
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Common side effects include:
dizzines
drowsiness
dry mouth
This medicine can cause excitement especially in children.
See a doctor immediately if you experience:
fast or irregular heartbeat
mental or mood changes
tightness in the chest
unusual tiredness or weakness.
While taking this medicine, if you experience, chest tightness, difficulty
in breathing or swallowing, swelling in the face or lips, go to the doctor
immediately and stop taking the medication until you have talked to your
doctor.
Warnings/Precautions
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Do NOT take this medicine with orange, apple or grapefruit juice. The levels
of this medicine in your blood may be decreased by 70%.
Overdose
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Seek medical attention immediately. For non emergencies, contact your local
or regional poison control center
Drug Interactions
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Before taking any other medications, by prescription or over-the-counter
(OTC) talk to your health care provider. Some medicines may change the way
this medicine affects your body. Also the effects of other medicines may
be increased or decreased by this medicine.
Pregnancy/Nursing
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Talk to your doctor about using this medicine during pregnancy or nursing
to discuss any possible risks to you or your baby.
More Information
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For more information about this medicine, talk to your healthcare provider
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Organismes affectes
Les humains et autres mammifères