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  • Deralin Formule chimique


    Deralin RX lien

    Deralin FDA fiche

    Deralin FDA

    Deralin msds (fiche de securite des materiaux)

    Deralin Synthese de reference

    Crowther, Smith, le brevet américain. 3,337,628 (1967)

    Deralin Poids moleculaire

    259.343 g/mol

    Deralin Point de fusion


    Deralin H2O Solubilite

    0,070 mg / ml (chlorhydrate de sel)

    Deralin Etat


    Deralin LogP


    Deralin Formes pharmaceutiques


    Deralin Indication

    Pour la prophylaxie de la migraine.

    Deralin Pharmacologie

    Le propranolol, le prototype des antagonistes des récepteurs bêta-adrénergiques, est une économie compétitive, un bêta-bloquant non sélectif similaire à nadolol sans activité sympathomimétique intrinsèque. Le propanolol est un composé racémique; l'isomère L est responsable de l'activité bloquant adrénergique.

    Deralin Absorption

    Le propranolol est presque complètement absorbé par le tractus gastro-intestinal, mais les concentrations plasmatiques atteintes sont très variables selon les individus.

    Deralin Toxicite

    Les symptômes de surdose comprennent une bradycardie, insuffisance cardiaque, hypotension, bronchospasme et l'. DL50 = 565 mg / kg (par voie orale chez la souris).

    Deralin Information pour les patients



    IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your
    physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe,
    appropriate, or effective for you. Consult your healthcare professional before using this drug.




    WARNING: If you have chest pain (angina) or heart disease (e.g., coronary artery disease, ischemic heart disease, high blood
    pressure), do not stop using this drug without first consulting your doctor. Your condition may become worse when the drug is
    suddenly stopped. If your doctor decides you should no longer use this drug, you must gradually decrease your dose according
    to your doctor's instructions.

    When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on
    the heart. Seek immediate medical attention if you develop: worsening chest pain, tightness or pressure in the chest, chest pain
    spreading to the jaw/neck/arm, sweating, trouble breathing or fast/irregular heartbeat.

    This medication is a beta-blocker used to treat chest pain (angina), high blood pressure, irregular heartbeats, migraine headaches,
    tremors, and other conditions as determined by your doctor. It is also used after an acute heart attack to improve survival.
    Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

    This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and
    blood vessels. This results in a lowering of heart rate, blood pressure, and strain on the heart.

    This medication has also been used for anxiety.

    Take this medication by mouth, as directed by your doctor. Use this medication regularly in order to get the most benefit from it.
    Remember to use it at the same time(s) each day.

    This drug is not effective if you use it only when chest pain or a migraine headache occurs. It is very important to take this
    medication regularly as prescribed to help prevent these conditions.

    The dosage is based on your medical condition and response to therapy. It may take 1 or 2 weeks before the full benefit of this
    drug takes effect. It is important to continue taking this medication even if you feel well. Most people with high blood pressure
    do not feel sick.

    Do not suddenly stop taking this medication without consulting your doctor. Your condition may become worse when the drug is suddenly
    stopped. Refer to the Warning section.

    You may experience dizziness, lightheadedness, drowsiness, tiredness, diarrhea, unusual dreams, trouble sleeping, or vision problems
    as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

    This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and
    avoid tobacco use.

    Tell your doctor immediately if any of these unlikely but serious side effects occur: symptoms of a very slow heartbeat (e.g.,
    persistent dizziness, fainting, unusual fatigue), bluish discoloration of the fingers and toes, numbness/tingling/swelling of the
    hands or feet, decreased sexual ability, reversible hair loss, mental/mood changes, trouble breathing, cough, unexplained or sudden
    weight gain, increased thirst, increased urination.

    Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: easy bruising or bleeding, persistent
    sore throat or fever.

    In the unlikely event you have a serious allergic reaction to this drug, seek medical attention immediately. Symptoms of a serious
    allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.

    If you notice other effects not listed above, contact your doctor or pharmacist.

    Before taking propranolol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

    This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or
    pharmacist if you have: certain types of irregular heartbeats (e.g., sinus bradycardia, second or third degree atrioventricular block),
    cardiogenic shock, severe heart failure (overt or decompensated type), asthma, a certain type of tumor (untreated pheochromocytoma).

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart failure (treated, compensated
    type), other breathing problems (e.g., chronic obstructive lung disease), diabetes, overactive thyroid disease (hyperthyroidism),
    kidney disease, liver disease, blood circulation problems (e.g., Raynaud's disease), skin conditions (e.g., psoriasis), mental/mood
    disorders (e.g., depression), certain muscle disease (myasthenia gravis).

    Before having surgery, tell your doctor or dentist that you are taking this medication.

    If you have diabetes, this medication may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls
    too low (hypoglycemia). Other symptoms of a low blood sugar level such as dizziness or sweating are unaffected by this drug.

    This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
    Limit alcoholic beverages.

    To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

    This drug should be used only when clearly needed during pregnancy. Discuss the risks (e.g., low birth weight) and benefits with your

    This drug passes into breast milk. Consult your doctor before breast-feeding.

    This drug should not be used with the following medications because very serious interactions may occur: mibefradil, certain psychiatric
    drugs (phenothiazines such as chlorpromazine, thioridazine).

    If you are currently using any of these medications, tell your doctor or pharmacist before starting this drug.

    Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially
    of: alpha-blockers (e.g., prazosin), certain antacids (aluminum hydroxide gel), anti-depressant drugs (e.g., amitriptyline, fluoxetine,
    paroxetine), anti-diabetic drugs (e.g., glipizide, glyburide, insulin), barbiturates (e.g., phenobarbital), calcium channel blockers
    (e.g., diltiazem, verapamil), cimetidine, epinephrine, ergotamine-like drugs, general anesthesia, haloperidol, other heart drugs (e.g.,
    amiodarone, digoxin, propafenone, quinidine, intravenous lidocaine), other drugs to treat high blood pressure (e.g., clonidine,
    hydralazine, methyldopa, reserpine), medications for overactive thyroid disease (e.g., methimazole, propylthiouracil), neuromuscular
    blocking drugs, non-steroidal anti-inflammatory drugs (e.g., indomethacin, ibuprofen), phenytoin, rifamycins (e.g., rifampin),
    rizatriptan, St. John's wort, theophylline.

    Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could
    increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products.

    This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

    Do not start or stop any medicine without doctor or pharmacist approval.

    If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national
    poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may
    include unusually slow heartbeat, severe dizziness, slow or shallow breathing, weakness, or fainting.

    Do not share this medication with others. Lifestyle changes such as stress reduction programs, exercise and dietary changes may increase
    the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

    Have your blood pressure and pulse checked regularly while taking this medication. It may be best to learn how to monitor your own blood
    pressure and pulse. Discuss this with your doctor.

    If you miss a dose, take it as soon as you remember, but not if it is within 4 hours of the next dose. If it is within 4 hours of the
    next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

    Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep
    all medicines away from children and pets.

    Deralin Organismes affectes

    Les humains et autres mammifères