3377 RP opalate

• Antirheumatic Agents
• Antimalarials
• Amebicides
• ATC:P01BA01
• ATC:P01BA02

• 3377 RP opalate
• Amokin
• Aralen
• Aralen HCl
• Arechin
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• Chloraquine
• Chlorochin
• Chlorochine
• Chloroquina
• Chloroquine (VAN)
• Chloroquine Phosphate
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• Clorochina
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• Nivaquine [as sulfate]
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No information avaliable

C₁₈H₂₆ClN₃

http://www.rxlist.com/cgi/generic2/hquine2.htm

3377_RP_opalate FDA

3377_RP_opalate MSDS

No hay información disponible

319.872 g/mol

289 ^oC

10.6 mg / L

Solid

4.474

Tableta

Para el tratamiento de supresión y para los ataques agudos de malaria por P. vivax, P. malariae, P. ovale y cepas susceptibles de P. falciparum, el agente de segunda línea en el tratamiento de la artritis reumatoide

La cloroquina es el medicamento prototipo contra la malaria, más ampliamente utilizados para tratar todos los tipos de malaria a excepción de la enfermedad causada por Plasmodium falciparum resistente a la cloroquina. Es muy eficaz contra formas eritrocíticas del Plasmodium vivax, Plasmodium ovale y Plasmodium malariae, las cepas sensibles de Plasmodium falciparum y gametocitos de Plasmodium vivax. Ser alcalina, la droga llega a la alta concentración dentro de las vacuolas de alimentos del parásito y eleva el pH. Se encuentra a inducir una rápida agregación del pigmento. Cloroquina inhibe la enzima polimerasa hemo parásito que convierte la hemo tóxicos en no es tóxico hemazoin, lo que resulta en la acumulación de hemo tóxicos dentro del parásito. También puede interferir con la biosíntesis de los ácidos nucleicos.

Completamente absorbido desde el tracto gastrointestinal

No hay información disponible

PATIENT INFORMATION

Complete blood cell counts should be made periodically if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered. The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

In patients with preexisting auditory damage, chloroquine should be administered with caution. In case of any defects in hearing, chloroquine should be immediately discontinued, and the patient closely observed.

Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures.

Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.

Irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapy. Retinopathy has been reported to be dose related.

Follow Rxlist link and drugs.com link for detailed patient information.

Plasmodium