Chloroquine Phosphate en es it fr

Chloroquine Phosphate Brand names, Chloroquine Phosphate Analogs

Chloroquine Phosphate Brand Names Mixture

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Chloroquine Phosphate Chemical_Formula


Chloroquine Phosphate RX_link

Chloroquine Phosphate fda sheet

Chloroquine_Phosphate FDA

Chloroquine Phosphate msds (material safety sheet)

Chloroquine_Phosphate MSDS

Chloroquine Phosphate Synthesis Reference

No information avaliable

Chloroquine Phosphate Molecular Weight

319.872 g/mol

Chloroquine Phosphate Melting Point

289 oC

Chloroquine Phosphate H2O Solubility

10.6 mg/L

Chloroquine Phosphate State


Chloroquine Phosphate LogP


Chloroquine Phosphate Dosage Forms


Chloroquine Phosphate Indication

For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis

Chloroquine Phosphate Pharmacology

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Being alkaline, the drug reaches high concentration within the food vacuoles of the parasite and raises its pH. It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.

Chloroquine Phosphate Absorption

Completely absorbed from gastrointestinal tract

Chloroquine Phosphate side effects and Toxicity

No information avaliable

Chloroquine Phosphate Patient Information


Complete blood cell counts should be made periodically if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered. The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

In patients with preexisting auditory damage, chloroquine should be administered with caution. In case of any defects in hearing, chloroquine should be immediately discontinued, and the patient closely observed.

Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures.

Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.

Irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapy. Retinopathy has been reported to be dose related.

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Chloroquine Phosphate Organisms Affected