3377 RP opalate en es it fr

3377 RP opalate Brand names, 3377 RP opalate Analogs

3377 RP opalate Brand Names Mixture

  • No information avaliable

3377 RP opalate Chemical_Formula


3377 RP opalate RX_link


3377 RP opalate fda sheet

3377_RP_opalate FDA

3377 RP opalate msds (material safety sheet)

3377_RP_opalate MSDS

3377 RP opalate Synthesis Reference

No information avaliable

3377 RP opalate Molecular Weight

319.872 g/mol

3377 RP opalate Melting Point

289 oC

3377 RP opalate H2O Solubility

10.6 mg/L

3377 RP opalate State


3377 RP opalate LogP


3377 RP opalate Dosage Forms


3377 RP opalate Indication

For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis

3377 RP opalate Pharmacology

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Being alkaline, the drug reaches high concentration within the food vacuoles of the parasite and raises its pH. It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids.

3377 RP opalate Absorption

Completely absorbed from gastrointestinal tract

3377 RP opalate side effects and Toxicity

No information avaliable

3377 RP opalate Patient Information


Complete blood cell counts should be made periodically if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered. The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

In patients with preexisting auditory damage, chloroquine should be administered with caution. In case of any defects in hearing, chloroquine should be immediately discontinued, and the patient closely observed.

Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures.

Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.

Irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapy. Retinopathy has been reported to be dose related.

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3377 RP opalate Organisms Affected