Zolmitriptan
Zolmitriptan Brand names, Zolmitriptan Analogs
Zolmitriptan Brand Names Mixture
- No information avaliable
Zolmitriptan Chemical_Formula
C16H21N3O2
Zolmitriptan RX_link
http://www.rxlist.com/cgi/generic2/zolmit.htm
Zolmitriptan fda sheet
Zolmitriptan msds (material safety sheet)
Zolmitriptan Synthesis Reference
No information avaliable
Zolmitriptan Molecular Weight
287.357 g/mol
Zolmitriptan Melting Point
No information avaliable
Zolmitriptan H2O Solubility
No information avaliable
Zolmitriptan State
Solid
Zolmitriptan LogP
1.363
Zolmitriptan Dosage Forms
Spray; Tablet
Zolmitriptan Indication
For the acute treatment of adult migraine (with or without auras)
Zolmitriptan Pharmacology
Zolmitriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Zolmitriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Zolmitriptan is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT1D family) having only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no significant affinity or pharmacological activity at 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1,; dopamine2; muscarinic, or benzodiazepine receptors. This action in humans correlates with the relief of migraine headache. In addition to causing vasoconstriction, experimental data from animal studies show that Zolmitriptan also activates 5-HT1 receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which may also contribute to the antimigrainous effect of Zolmitriptan in humans.
Zolmitriptan Absorption
40%
Zolmitriptan side effects and Toxicity
No information avaliable
Zolmitriptan Patient Information
No information avaliable
Zolmitriptan Organisms Affected
Humans and other mammals
