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Velcade Brand names, Velcade Analogs

Velcade Brand Names Mixture

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Velcade Chemical_Formula


Velcade RX_link

Velcade fda sheet

Velcade FDA

Velcade msds (material safety sheet)

Velcade Synthesis Reference

No information avaliable

Velcade Molecular Weight

384.237 g/mol

Velcade Melting Point

No information avaliable

Velcade H2O Solubility

The solubility of bortezomib, as the monomeric boronic acid, is 3.3 to 3.8 mg/mL in a pH range of 2 to 6.5.

Velcade State


Velcade LogP

No information avaliable

Velcade Dosage Forms

Powder for intravenous injection solution (each single dose vial contains 3.5 mg of bortezomib)

Velcade Indication

For treatment of multiple myeloma in patients who have not been successfully treated with at least two previous therapies.

Velcade Pharmacology

Bortezomib is a drug that inhibits the mammalian 26S proteasome. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome prevents this targeted proteolysis, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Experiments have demonstrated that bortezomib is cytotoxic to a variety of cancer cell types in vitro. Bortezomib causes a delay in tumor growth in vivo in nonclinical tumor models, including multiple myeloma. Tumor cells, that is, rapidly dividing cells, appear to be more sensitive to proteasome inhibition.

Velcade Absorption

No information avaliable

Velcade side effects and Toxicity

Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration.

Velcade Patient Information

No information avaliable

Velcade Organisms Affected

Humans and other mammals