Velcade
Velcade Brand names, Velcade Analogs
Velcade Brand Names Mixture
- No information avaliable
Velcade Chemical_Formula
C19H25BN4O4
Velcade RX_link
http://www.rxlist.com/cgi/generic3/velcade.htm
Velcade fda sheet
Velcade msds (material safety sheet)
Velcade Synthesis Reference
No information avaliable
Velcade Molecular Weight
384.237 g/mol
Velcade Melting Point
No information avaliable
Velcade H2O Solubility
The solubility of bortezomib, as the monomeric boronic acid, is 3.3 to 3.8 mg/mL in a pH range of 2 to 6.5.
Velcade State
Solid
Velcade LogP
No information avaliable
Velcade Dosage Forms
Powder for intravenous injection solution (each single dose vial contains 3.5 mg of bortezomib)
Velcade Indication
For treatment of multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
Velcade Pharmacology
Bortezomib is a drug that inhibits the mammalian 26S proteasome. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome prevents this targeted proteolysis, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Experiments have demonstrated that bortezomib is cytotoxic to a variety of cancer cell types in vitro. Bortezomib causes a delay in tumor growth in vivo in nonclinical tumor models, including multiple myeloma. Tumor cells, that is, rapidly dividing cells, appear to be more sensitive to proteasome inhibition.
Velcade Absorption
No information avaliable
Velcade side effects and Toxicity
Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration.
Velcade Patient Information
No information avaliable
Velcade Organisms Affected
Humans and other mammals
