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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C32H32O13S
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RX_link
http://www.rxlist.com/cgi/generic2/teniposide.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
656.655 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
1.963
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Dosage Forms
Liquid
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Indication
Treatment of refractory acute lymphoblastic leukaemia
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Pharmacology
Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals