Teniposidum [Inn-Latin]
Brand names,
Teniposidum [Inn-Latin]
Analogs
Teniposidum [Inn-Latin]
Brand Names Mixture
Teniposidum [Inn-Latin]
Chemical_Formula
C32H32O13S
Teniposidum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic2/teniposide.htm
Teniposidum [Inn-Latin]
fda sheet
Teniposidum [Inn-Latin]
msds (material safety sheet)
Teniposidum [Inn-Latin]
Synthesis Reference
No information avaliable
Teniposidum [Inn-Latin]
Molecular Weight
656.655 g/mol
Teniposidum [Inn-Latin]
Melting Point
No information avaliable
Teniposidum [Inn-Latin]
H2O Solubility
No information avaliable
Teniposidum [Inn-Latin]
State
Solid
Teniposidum [Inn-Latin]
LogP
1.963
Teniposidum [Inn-Latin]
Dosage Forms
Liquid
Teniposidum [Inn-Latin]
Indication
Treatment of refractory acute lymphoblastic leukaemia
Teniposidum [Inn-Latin]
Pharmacology
Teniposide is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle, thus preventing cells from entering mitosis. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA: protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.
Teniposidum [Inn-Latin]
Absorption
No information avaliable
Teniposidum [Inn-Latin]
side effects and Toxicity
No information avaliable
Teniposidum [Inn-Latin]
Patient Information
No information avaliable
Teniposidum [Inn-Latin]
Organisms Affected
Humans and other mammals