Vardenafil

• Anti-Impotence Agents
• Vasoconstrictor Agents
• Phosphodiesterase Inhibitors
• ATC:G04BE09

• Levitra
• VARDENAFIL, LEVITRA
• VDN

• No information avaliable

C₂₃H₃₂N₆O₄S

http://www.rxlist.com/cgi/generic3/levitra.htm

Vardenafil FDA

No information avaliable

488.604 g/mol

192 ^oC

0.11 mg/mL (HCl salt)

Solid

No information avaliable

Tablet (5, 10, and 20 mg)

Used for the treatment of erectile dysfunction

Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Symptoms of overdose include vision changes and back and muscle pain.

Humans and other mammals