Vardenafil
Vardenafil Brand names, Vardenafil Analogs
Vardenafil Brand Names Mixture
- No information avaliable
Vardenafil Chemical_Formula
C23H32N6O4S
Vardenafil RX_link
http://www.rxlist.com/cgi/generic3/levitra.htm
Vardenafil fda sheet
Vardenafil msds (material safety sheet)
Vardenafil Synthesis Reference
No information avaliable
Vardenafil Molecular Weight
488.604 g/mol
Vardenafil Melting Point
192 oC
Vardenafil H2O Solubility
0.11 mg/mL (HCl salt)
Vardenafil State
Solid
Vardenafil LogP
No information avaliable
Vardenafil Dosage Forms
Tablet (5, 10, and 20 mg)
Vardenafil Indication
Used for the treatment of erectile dysfunction
Vardenafil Pharmacology
Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.
Vardenafil Absorption
Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.
Vardenafil side effects and Toxicity
Symptoms of overdose include vision changes and back and muscle pain.
Vardenafil Patient Information
Vardenafil Organisms Affected
Humans and other mammals
