VARDENAFIL, LEVITRA

VARDENAFIL, LEVITRA Brand names, VARDENAFIL, LEVITRA Analogs

VARDENAFIL, LEVITRA Brand Names Mixture

No information avaliable

VARDENAFIL, LEVITRA Chemical_Formula

C₂₃H₃₂N₆O₄S

VARDENAFIL, LEVITRA RX_link

http://www.rxlist.com/cgi/generic3/levitra.htm

VARDENAFIL, LEVITRA fda sheet

VARDENAFIL,_LEVITRA FDA

VARDENAFIL, LEVITRA msds (material safety sheet)

VARDENAFIL, LEVITRA Synthesis Reference

No information avaliable

VARDENAFIL, LEVITRA Molecular Weight

488.604 g/mol

VARDENAFIL, LEVITRA Melting Point

192 ^oC

VARDENAFIL, LEVITRA H₂O Solubility

0.11 mg/mL (HCl salt)

VARDENAFIL, LEVITRA State

Solid

VARDENAFIL, LEVITRA LogP

No information avaliable

VARDENAFIL, LEVITRA Dosage Forms

Tablet (5, 10, and 20 mg)

VARDENAFIL, LEVITRA Indication

Used for the treatment of erectile dysfunction

VARDENAFIL, LEVITRA Pharmacology

Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

VARDENAFIL, LEVITRA Absorption

Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

VARDENAFIL, LEVITRA side effects and Toxicity

Symptoms of overdose include vision changes and back and muscle pain.

VARDENAFIL, LEVITRA Patient Information

VARDENAFIL, LEVITRA Organisms Affected

Humans and other mammals