Levitra
Levitra Brand names, Levitra Analogs
Levitra Brand Names Mixture
- No information avaliable
Levitra Chemical_Formula
C23H32N6O4S
Levitra RX_link
http://www.rxlist.com/cgi/generic3/levitra.htm
Levitra fda sheet
Levitra msds (material safety sheet)
Levitra Synthesis Reference
No information avaliable
Levitra Molecular Weight
488.604 g/mol
Levitra Melting Point
192 oC
Levitra H2O Solubility
0.11 mg/mL (HCl salt)
Levitra State
Solid
Levitra LogP
No information avaliable
Levitra Dosage Forms
Tablet (5, 10, and 20 mg)
Levitra Indication
Used for the treatment of erectile dysfunction
Levitra Pharmacology
Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.
Levitra Absorption
Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.
Levitra side effects and Toxicity
Symptoms of overdose include vision changes and back and muscle pain.
Levitra Patient Information
Levitra Organisms Affected
Humans and other mammals
