Vanobid
Vanobid Brand names, Vanobid Analogs
Vanobid Brand Names Mixture
- No information avaliable
Vanobid Chemical_Formula
C12H17NO2
Vanobid RX_link
http://www.rxlist.com/cgi/generic3/penlac.htm
Vanobid fda sheet
Vanobid msds (material safety sheet)
Vanobid Synthesis Reference
No information avaliable
Vanobid Molecular Weight
207.269 g/mol
Vanobid Melting Point
144 oC
Vanobid H2O Solubility
No information avaliable
Vanobid State
Solid
Vanobid LogP
2.33
Vanobid Dosage Forms
Topical solution (8%)
Vanobid Indication
Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum.
Vanobid Pharmacology
Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Ciclopirox exhibits either fungistatic or fungicidal activity in vitro against a broad spectrum of fungal organisms, such as dermatophytes, yeasts, dimorphic fungi, eumycetes, and actinomycetes. In addition to its broad spectrum of action, ciclopirox also exerts antibacterial activity against many Gram-positive and Gram-negative bacteria. Furthermore, the anti-inflammatory effects of ciclopirox have been demonstrated in human polymorphonuclear cells, where ciclopirox has inhibited the synthesis of prostaglandin and leukotriene. Ciclopirox can also exhibit its anti-inflammatory effects by inhibiting the formation of 5-lipoxygenase and cyclooxygenase.
Vanobid Absorption
Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.
Vanobid side effects and Toxicity
Oral LD50 in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache.
Vanobid Patient Information
No information avaliable
Vanobid Organisms Affected
Humans, other mammals, yeast and other fungi
