Candicidin D en es it fr

Candicidin D Brand names, Candicidin D Analogs

Candicidin D Brand Names Mixture

  • No information avaliable

Candicidin D Chemical_Formula


Candicidin D RX_link

Candicidin D fda sheet

Candicidin_D FDA

Candicidin D msds (material safety sheet)

Candicidin_D MSDS

Candicidin D Synthesis Reference

No information avaliable

Candicidin D Molecular Weight

207.269 g/mol

Candicidin D Melting Point

144 oC

Candicidin D H2O Solubility

No information avaliable

Candicidin D State


Candicidin D LogP


Candicidin D Dosage Forms

Topical solution (8%)

Candicidin D Indication

Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum.

Candicidin D Pharmacology

Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Ciclopirox exhibits either fungistatic or fungicidal activity in vitro against a broad spectrum of fungal organisms, such as dermatophytes, yeasts, dimorphic fungi, eumycetes, and actinomycetes. In addition to its broad spectrum of action, ciclopirox also exerts antibacterial activity against many Gram-positive and Gram-negative bacteria. Furthermore, the anti-inflammatory effects of ciclopirox have been demonstrated in human polymorphonuclear cells, where ciclopirox has inhibited the synthesis of prostaglandin and leukotriene. Ciclopirox can also exhibit its anti-inflammatory effects by inhibiting the formation of 5-lipoxygenase and cyclooxygenase.

Candicidin D Absorption

Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.

Candicidin D side effects and Toxicity

Oral LD50 in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache.

Candicidin D Patient Information

No information avaliable

Candicidin D Organisms Affected

Humans, other mammals, yeast and other fungi