PharmacyCodes



VFEND en es it fr

VFEND Brand names, VFEND Analogs

VFEND Brand Names Mixture

  • No information avaliable

VFEND Chemical_Formula

C16H14F3N5O

VFEND RX_link

http://www.rxlist.com/cgi/generic/vfend.htm

VFEND fda sheet

VFEND FDA

VFEND msds (material safety sheet)

VFEND MSDS

VFEND Synthesis Reference

No information avaliable

VFEND Molecular Weight

349.311 g/mol

VFEND Melting Point

127 - 130 oC

VFEND H2O Solubility

Low

VFEND State

Solid

VFEND LogP

2.561

VFEND Dosage Forms

Tablet; Oral suspension; IV injection

VFEND Indication

For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.

VFEND Pharmacology

Voriconazole is a triazole antifungal agent indicated for use in the treatment of fungal infections including invasive aspergillosis, esophageal candidiasis, and serious fungal infections caused by Scedosporium apiospermum (asexual form of Pseudallescheria boydii) and Fusarium spp. including Fusarium solani. Fungal plasma membranes are similar to mammalian plasma membranes, differing in having the nonpolar sterol ergosterol, rather than cholesterol, as the principal sterol. Membrane sterols such as ergosterol provide structure, modulation of membrane fluidity, and possibly control of some physiologic events. Voriconazole effects the formation of the fungal plasma membrane by indirectly inhibiting the biosynthesis of ergosterol. This results in plasma membrane permeability changes and inhibition of growth.

VFEND Absorption

The oral bioavailability is estimated to be 96% (CV 13%).

VFEND side effects and Toxicity

The minimum lethal oral dose in mice and rats was 300 mg/kg (equivalent to 4 and 7 times the recommended maintenance dose (RMD), based on body surface area). At this dose, clinical signs observed in both mice and rats included salivation, mydriasis, titubation (loss of balance while moving), depressed behavior, prostration, partially closed eyes, and dyspnea. Other signs in mice were convulsions, corneal opacification and swollen abdomen.

VFEND Patient Information

VFEND Organisms Affected

Yeast and other fungi